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Viv-20

• | Product Spec Pdf
• | Typical COA Pdf
• | Product brochure Pdf
• | Msds Pdf

Application

• Oral Care (Tooth pastes and mouth washes)
• Personal Hygiene and cosmetics (Skin lotions, creams and deodorants)
• Hair care (Bath and shower Toiletries)
• Dish washing products.
• Laundry detergents and softeners (Laundry bars, liquid and powderdetergents)
• Disinfectant.
• Textile and Paper treatment.
• Food contact additive in plastics.

Synthesis and special purification methodologies

Triclosan belongs to a group of Organic entities classified under the category of Hydroxy-poly halogenated diphenyl ethers. The molecular structure suggests a delicate Hydrophilic - lipophilic balance, responsible for the antibacterial activity. Triclosan has emerged over the years as the most powerful antibacterial due to its broad bactericidal properties & an acceptable toxicological profile.

Triclosan is synthesized by a "prestructured sequence" meaning that all major functionalities are incorporated at early stages of its complex synthesis, hence leading to predetermined levels of purity and activity.

The last element of the synthetic sequence culminates in the Hydrolytic substitution reaction, which yields Triclosan.

Purification: To give our customers the best and the most reproducible quality of the product a series of columnar reverse extractions are performed; followed by High Vacuum distillation and crystallization. All these complex processes are at all steps controlled by in process QA backed by PDA monitored HPLCs.

Analytical contents & QA:
All the raw materials are monitored from stage - 1 for their purity, side impurity profile, odor, physical parameters and vendor reproducibility. Diverse techniques like FT-IR, MPLC, HPTLC, PDA-HPLC and GC-MS are incorporated in our analytical sequencing to predetermine quality at all levels. All the manufacturing and analytical methods employed in the synthesis of Triclosan are validated.

HPLC Chromatograph

Heavy Metal Specifications

Item	Limit	Analytically Analyzed
Arsenic	< 2 mg/kg	< 0.03 mg/kg
Mercury	< 1 mg/kg	< 0.05 mg/kg
Lead	< 10mg/kg	< 0.03 mg/kg
Nickel	< 10mg/kg	< 0.03 mg/kg
Antimony	>10mg/kg	>0.02 mg/kg
Copper	< 10mg/kg	< 0.03 mg/kg
Chromium	< 2 mg/kg	< 0.04 mg/kg
Cadmium	< 5 mg/kg	< 0.02 mg/kg

Impurity Profile

Special HPLC tests are performed as
per the USP XXVI to ascertain the "Level Compliance" of:

Item	Limit	Analytically Analyzed
2,8-Dichlorodibenzo-furan	< 0.25 ppm	0.022 ppm
2,8-Dichlorodibenzo-p-dioxin	< 0.5 ppm	0.03 ppm
2,4,8-Trichlorodibenzo-furan	< 0.5 ppm	0.05 ppm
1,3,7-Trichlorodibenzo-p-dioxin	< 0.25 ppm	0.034 ppm

Impurity level measurements for two other impurities 2,3,7,8 TCDD and 2,3,7,8 TC DF are conducted employing GC - MS high-resolution technique at the Laboratory of M/s. Marchwood Scientific services, UK.

STABILITY:

To ascertain the stability of our product re-testing data is an in-house mandatory specification. Accelerated stability testing and thermal degradation methods are routinely applied to our product to ascertain even the minutest changes.

ECO - friendly manufacturing

Maximum care is taken not just to protect the environment; but also enhance it byafforestations. Water, air and ground water samples are regularly processed for assessing the environmental impact of our product.

Sustained dermal activity
The finger imprint tests clearly indicate the long lasting effects of Triclosan in creating a bacteria free environment not just during the wash time but also thereafter. Clearly leading us to conclude that the exposed organs are protected in a sustained fashion.

Irritation modulator Triclosan effectively controls irritation & inflammation processes by inhibiting the function of lipoxygenase and cyclo –oxygenase enzymes.

Anti odor propertiesTemporary or persistent foul odor, emitted by fibers in contact with body parts or by underexposed arm pits, oral cavity, and skin can be contained by Triclosan containing cosmetics or “formulations”. Undergarments adsorbed with Triclosan serve both the purposes i.e. antisepsis as well as odor control.

Influence on the dermal flora
Quantitative data documented in different labs has conclusively established that Triclosan treated skin retains its ability to cultivate the favorable flora.

Pre-formulations offered

Since ease of the unit process, employed by our customer is central to our business, we also cater to customer-oriented pre-formulations. All these pre-formulations are equipped with solvents & co-solvents as per the needs of the industry and the regulatory aspects of the country concerned.

Application area

• Oral
• Dermal
• Household
• Plastics & Polymers
• Textiles
• Industrial

Application area

VIV-20:Triclosan has been synonymous with the personal care & product based hygienic Industry, enduring successfully a time-tested path for its activity as well as safety. The twin driving forces apart from creating a unique anti microbial also have paved ways into cutting edge markets catering not just to curative but also to prophylactic and preventive segments. The one punch and also sustained anti microbial activity profile has packed in this molecule a broad spectrum of activity which can go into a wide variety of products like tooth pastes, deodorants, creams and gels and the unconventional new areas like hard surface, polymer, plastics and fibers.

VIV-20 IN ORAL CARE
Triclosan in concentration ranging from 0.1 to 0.3 is a valuable anti bacterial used in toothpaste & mouth wash formulations, with its decisive single punch. The highest punch per unit time bactericide provides complete 24 hrs cover to the oral cavity against a host of fungal and bacterial organisms. Triclosan can be easily formulated & incorporated into Creams, Gels and Pastes.

VIV-20 IN PLASTICS & POLYMERS
Special extrusion processes are employed to incorporate Triclosan into the plastic - polymer matrix, hence creating inbuilt antibacterial properties. Studies have revealed that with inbuilt levels of Triclosan, plastics & polymers offer longer and most durable anti-bacterial effects.

VIV-20 IN DEODORANTS
A strong reduction in body malodor can be achieved with low concentrations of VIV-20. Recommended concentration (0.15%-0.20%).

VIV-20 has fast and long lasting action in reduction of skin bacteria of axillae thereby restoring the initial healthy skin flora. VIV-20 is very safe on the skin even under long term usage. VIV-20 can counteract the effects of surfactants by reducing its irritation potential in the formulation.VIV-20 is soothing on irritated skin and helps in the healing of affected skin. VIV-20 can be incorporated in : Aerosols, Sticks, Rollons, gels etc.

VVIV-20 IN HAND CREAMS
VIV-20 has long lasting anti -bacterial effects against pathogenic gram+and gram- bacteria thus reducing the risk of contamination with pathogenic bacteria. VIV-20 provides good protection in high risk situations of day to day life against transfer of pathogenic bacteria like in food handling.VIV-20 containing products have a high water resistance. Even after several rinsing cycles, hands rubbed with VIV-20 are well protected against growth of pathogens. Microbiological studies have shown VIV-20 is effective against Salmonell&Staphylococcus aureus which play a role in cross-contamination ( MIC is 0.5ppm&0.1ppm respectively).

VIV-20 IN SHAVING PRODUCTS
Microbiological studies have shown VIV-20 containing products have long lasting broad spectrum anti-bacterial activity. For example Staphylococcus aureus & Eschericia coli) Duration of protection of skin upto 24 hrs can be provided by varying the concentration of VIV-20 in its products.The irritation potential of surfactants in the formulation can be reduced by VIV-20. It is effective in after-shave products providing long lasting anti bacterial effects.

VIV-20 IN FOOT CARE PRODUCTS
VIV-20 can be used in various foot-care products to counteract the foot malodour causing bacteria like Micrococcus luteus.VIV-20 also provides a shield against dermatophytes and be helpful in preventing athlete's foot. VIV-20 can be incorporated in Sprays, Insoles, Powders Gels, etc.

VIV-20 IN ANTI-ACNE PRODUCTS
VIV-20 containing anti-acne products provide a long lasting anti bacterial activity against acne causing bacteria. VIV-20 is effective in preventing the growth of Staphylococcus aureus in the inflamed pustles.